Researchers at Kanazawa University have studied the structure of one of the virulence factors – haemagglutinin (HA) – of avian influenza virus, H5N1. They did this using high-speed atomic force microscopy (HS-AFM) and the findings are essential for developing therapeutic approaches against influenza A viruses in the future. Understanding the structure and properties of HA when it is initially synthesised by host cells in its precursor form (HA0) is paramount to deciphering HA. So Dr Richard Wong, senior author of the study, and his research team visually analysed the recombinant HA0 protein of H5N1 with the HS-AFM system developed by ...
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A study published on 26 April in Science saw that researchers have discovered an acid-activated protein which could prevent tissue damage from stroke, heart attack, cancer and inflammation. The researchers at John Hopkins University School of Medicine named the newly found protein the proton-activated chloride channel (PAC). The team believes the discovery of this protein could provide a new drug target for potential therapies for stroke and other health issues. Damage or disease, leading to oxygen deprivation, causes a raised level of acid in tissues. If acidity increases enough the cells become damaged and potentially die. When the build-up of ...
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Artificial Intelligence (AI) has been at the top of many boardroom agendas for the last several years, as execs try to integrate the technology. Recent RELX research found that, across all industries, 88 percent of senior executives believe AI will help their businesses be more competitive. In the life sciences, AI has the potential to scale the benefits of precision medicine or automated disease prediction to more patients across the world, and could generate more than $150 billion in savings for the healthcare industry by 2025. 3d rendering robot hand working with security laptop Artificial Intelligence (AI) has been at ...
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Researchers from King’s College London have shown how skin vaccination can generate protective CD8 T-cells that are recruited to the genital tissues and could be used as a vaccination strategy for STIs. Before this study, it was thought that vaccines ideally needed to be delivered directly to the body surface where the infection might start, so that the immune system can generate these CD8 T-cells, travel back to the vaccination site and eliminate any future virus that is encountered. However, delivering vaccines directly to the female genital tissue is neither patient-friendly nor efficient. Now the team from King’s have found ...
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Istanbul, Turkey – September 6, 2015: A woman wearing 42mm stainless steel Apple Watch with white sports band. The Apple Watch became available April 24, 2015, bringing a new way to receive information at a glance, using apps designed specifically for the wrist. Apple is a company that has long been thought of us an innovator that has brought consumers an array of enticing gadgets, from home computers to iPods to smartphones. This technology has been transformative for its users, but mostly it has been associated with work and play. Increasingly, though, Apple appears to be interested in getting involved ...
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AI in Drug Discovery Has Great Potential – But Also Significant Barriers It’s an exciting new time for drug discovery and development as whole new worlds of data have opened up. Wearable devices that collect personal health readings and services such as consumer genetic testing are making loads of potentially insightful data available. But all that potential comes with new challenges – namely, how do we process and analyze all this new data? Artificial intelligence presents a timely answer to this problem. AI has an array of useful applications in pharma, whether it’s identifying candidates for drug repurposing or assessing ...
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The scientists, funded by the National Institute of Allergy and Infectious Diseases (NIAID), discovered and characterised the structure of a naturally occurring human antibody that recognises and disrupts a portion of the hemagglutinin (HA) protein that the influenza virus uses to enter and infect cells. The investigators determined that the antibody, FluA-20, binds tightly to an area on the globular head of the HA protein that is only very briefly accessible to antibody attack.  The team, led by James E. Crowe, Jr, MD, of Vanderbilt University Medical Centre, Nashville, Tennessee, and Ian A Wilson, DPhil., of The Scripps Research Institute, ...
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New Legal Site Launches ChrisCoffman.Rocks We had a little fun with the name I will admit that.  Honestly I wasn’t even aware that .rocks was a valid domain, it feels more like an 80s throwback which predates the internet.  With that said it is memorable and I’ve gone with it. Hall of Justice in Louisville, KY Chris Coffman is in fact an attorney in Louisville, KY whom I’ve known for twenty years.  Which is likely the only reason why he agreed to allow me to toss up a site in his name and SEO it.  Chris has been told over ...
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Elsevier is recognized as ‘Best of Show Award Finalist’ and ‘People’s Choice Award Finalist” at Bio-IT World Conference & Expo 2019 For more than a decade, the pharmaceutical and life science community has had an annual opportunity to join the Bio-IT World Conference & Expo, an event where pharmaceutical and life science industry leaders and experts come together to represent their companies, share ideas, domain knowledge, best practices and achievements in R&D and technology areas. The Bio-IT World Conference & Expo 2019 welcomed 3,400+ life sciences, pharmaceutical, clinical, healthcare and IT professionals from 40+ countries. To encourage and appreciate the ...
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The researchers’ Y-shaped block catiomer (YBC) binds with certain therapeutic materials to form a package that is 18 nanometers wide – this is less than one-fifth the size of those produced in previous studies, so can pass through much smaller gaps. This allows YBCs to slip through tight barriers in cancers of the brain or pancreas. A promising field in the fight against cancer is gene therapy, which targets genetic causes of diseases to reduce their effect. The idea is to inject a nucleic acid-based drug into the bloodstream – typically small interfering RNA (siRNA) – which binds to a ...
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The Cancer-Killing Nanorobots are Coming Scientists have shown –and continue to show – endless ingenuity as they develop drugs and therapies that can help the body fight cancer. But sometimes, in order to be fully effective, medicines need a little ‘helping hand’ as they do their work inside a patient. Nanorobots are a developing technology that have the potential to provide that assistance. Targeting Tumors One of the most exciting breakthroughs in nanomedicine came just last year when scientists at Arizona State University, working in conjunction with National Center for Nanoscience and Technology (NCNST) researchers, announced that they had used ...
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